Neofolione®

Other comments :

The structural resemblance with Methyl Octyl Carbonate explains their similarity in terms of smell. However, Neofolione® is much more aldehyde and metallic.

Stability :

Esters may form their corresponding acid through time
Unstable in acidic products, except antiperspirants, and very alkaline products

Uses in perfumery :

Neofolione® is most often used in home care, detergents, fabric care and shampoos. Used in small quantities because of its power. Interesting for fruity notes and aldehydic floral notes for a fresh touch. Provides freshness and diffusion. Often used as a replacor of Methyl Octine Carbonate.

Year of discovery :

Data not available.

Isomerism :

Neofolione® has a double bond that offers the possibility of obtaining two diastereoisomers for this molecule. In perfumery, Neofolione® is a racemic mixture of these two isomers. The two isomers are not separated as they have no olfactory interest. In addition, Gamma-Decalactone and Linalool Oxide are constitutional isomers of Neofolione®. However, they have a very different smell.

Synthesis precursor :

Neofolione® is not a precursor to the synthesis of another compound of olfactory interest.

Natural availability :

Neofolione® is one of the compounds of the fragrant principle of artichoke. However, it cannot be extracted.

Synthesis route :

The synthesis of Neofolione® is made from Heptanal (Aldehyde C-7), condensed with malonic acid. This reaction is carried out in an acid medium. Then, follows a decarboxylation of the compound to remove the second acid function of the malonic acid, and a final step of esterification of the obtained molecule with methanol. This step requires an acid catalysis (with sulfuric acid for example) to improve the reaction yield.