Gamma-dodecalactone

Other comments :

Stability :

Lactones tend to polymerize through time, making them more viscous and leading to a phase shift in alcohol.

Uses in perfumery :

Used to bring warm, creamy facets. Very good with fruity notes. Also used to ''smooth '' a accord.

Year of discovery :

Data not available.

Isomerism :

Gamma-Dodecalactone has an asymetric carbon. Nevertheless, we always use its racemic mixture in perfumery. Delta-dodécalactone is an isomer of Decalactone-Gamma, which has one less carbon atom into its ring, but one more in its ramified carbon chain. The resulting odor changes from a metallic peach and coconut odor to a fruity peach odor

Synthesis precursor :

Gamma-Dodecalactone is not a precursor to the synthesis of another compound of olfactory interest.

Natural availability :

Data not available.

Synthesis route :

Gamma-Dodecalactone is part of the gamma-lactone family: cyclic esters whose ring is made up of five atoms. This molecule is a cyclic lactone synthesized in the similar way as other lactones. The reaction between acrylic acid and butanol, in the presence of an alkaline sulphate or phosphate allows this molecule to be synthesized. Intramolecular esterification of 4-hydroxyheptanoic acid, catalyzed by a strong acid such as concentrated sulfuric acid, also makes it possible. Finally, biochemical synthesis routes are being studied by the producing companies.