Sulfurol

Other comments :

Sulfurol is part of the thiazole family. These are components with extremely low detection thresholds. Then, only a small quantity in composition can bring a significative effect.

Stability :

As it can form Schiff bases by reacting with aldehydes, Sulfurol can be responsible for coloration in some perfume concentrates and in eaux de toilette, among others.

Uses in perfumery :

Sulfurol is used in sandalwood and fruity notes, to sustain a milky and creamy effect, to bring sweetness and for rounding the note.

Year of discovery :

1935

Isomerism :

Sulfurol does not have any isomer commonly used in perfumery.

Synthesis precursor :

Sulfurol can be used to synthetise Schiff bases, but those are very rarely synthesized. These bases are made by a reactions between Sulfurol and various aldehydes or ketones.

Natural availability :

Sulfurol is present in some grilled meats, in alcoholic beverages (cognac and whiskey among others), in Cocoa Absolut and in peanuts among others, from which it cannot be extracted. Only synthetic Sulfurol is used in perfumery.

Synthesis route :

Two ways of synthesis can be used to make Sulfurol. The first one is a reduction of 4-ethyl-5-methylthiazole acetate, by reacting with lithium aluminium hydride, a very strong reductor. Another synthesis route is a condensation reaction between thioformamide and bromoacetopropanol. In this second reaction, both molecules are fusing into a single one, in an acidic medium.